MolNFT v1 · #21198 · protein

Purine 2'DEOXYRIBOSYLTRANSFERASE native structure

1S2L · Purine trans deoxyribosylase: “Purine 2'DEOXYRIBOSYLTRANSFERASE native structure”. X-ray diffraction, 13 pockets (best druggability 0.73). MolNFT v1 #21198 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1S2L
Type: protein
Length: 485 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Purine trans deoxyribosylase
EC: 2.4.2.6
UniProt: Q8RLY5
Pockets: 13 · best druggability 0.73

Structure

x-ray diffraction · 3 distinct chains · 35% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Purine trans deoxyribosylase (EC 2.4.2.6)	protein	165	34% helix, 19% strand	Q8RLY5
B	Purine trans deoxyribosylase (EC 2.4.2.6)	protein	167	34% helix, 19% strand	Q8RLY5
C	Purine trans deoxyribosylase (EC 2.4.2.6)	protein	153	37% helix, 20% strand	Q8RLY5

Pockets

13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	218	0.73	0.89	27	empty
2	80	0.62	0.90	16	empty
3	207	0.52	0.77	32	empty
4	219	0.50	0.76	31	empty
5	76	0.39	0.78	18	empty

Interfaces

3 interfaces between chains.

B–C · 955 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 846 Å² buried · 12 hydrogen bonds · protein-protein
A–C · 744 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1S2L · Purine 2'deoxyribosyltransferase native structure · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8RLY5
Elsewhere: RCSB PDB 1S2L · PDBe 1S2L · UniProt Q8RLY5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.