MolNFT v1 · #21142 · protein

EIF2GAMMA apo

1S0U · Translation initiation factor 2 gamma subunit: “EIF2GAMMA apo”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.47). MolNFT v1 #21142 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1S0U
Type: protein
Length: 391 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translation initiation factor 2 gamma subunit
UniProt: Q58657
Ligands: ZN
Pockets: 3 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Translation initiation factor 2 gamma subunit	protein	391	15% helix, 39% strand	Q58657

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	191	0.47	0.75	30	empty
2	92	0.43	0.79	17	empty
3	60	0.27	0.73	16	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1S0U · eIF2gamma apo · the same entry in another collection · chain A against A, TM-score 1.00
Q58657 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit gamma… · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q58657
Elsewhere: RCSB PDB 1S0U · PDBe 1S0U · UniProt Q58657

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