MolNFT v1 · #20905 · protein

Crystal structure of S. aureus farnesyl pyrophosphate synthase

1RTR · Geranyltranstransferase: “Crystal structure of S. aureus farnesyl pyrophosphate synthase”. X-ray diffraction, 4 pockets (best druggability 0.72). MolNFT v1 #20905 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1RTR
Type: protein
Length: 548 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Geranyltranstransferase
UniProt: Q8NWD6
Pockets: 4 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Geranyltranstransferase	protein	277	73% helix, 1% strand	Q8NWD6
B	Geranyltranstransferase	protein	271	72% helix, 1% strand	Q8NWD6

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	592	0.72	0.80	61	empty
2	522	0.71	0.80	53	empty
3	128	0.45	0.77	34	empty
4	89	0.36	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 2229 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

1RTR · Crystal Structure of S. Aureus Farnesyl Pyrophosphate Synthase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NWD6
Elsewhere: RCSB PDB 1RTR · PDBe 1RTR · UniProt Q8NWD6

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