MolNFT v1 · #20835 · protein

Soybean lipoxygenase (lox-3) at ambient temperatures at 2.0 a resolution

1RRH · Seed lipoxygenase-3: “Soybean lipoxygenase (lox-3) at ambient temperatures at 2.0 a resolution”. X-ray diffraction, 1 ligand (FE2), 10 pockets (best druggability 0.81). MolNFT v1 #20835 on GenesisL1: 3D structure, binding sites and…

PDB: 1RRH
Type: protein
Length: 850 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Seed lipoxygenase-3
EC: 1.13.11.12
UniProt: P09186
Ligands: FE2
Pockets: 10 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Seed lipoxygenase-3 (EC 1.13.11.12)	protein	850	40% helix, 15% strand	P09186

Ligands and binding sites

FE2 · Fe (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	701	0.81	0.85	71	empty
2	57	0.73	0.99	22	empty
3	554	0.72	0.80	45	empty
4	404	0.71	0.82	51	empty
5	50	0.57	0.91	15	empty

Compared structures

1RRH · Soybean Lipoxygenase (LOX-3) at ambient temperatures at 2.0 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
P09186 · AlphaFold monomer V2.0 prediction for seed linoleate 9S-lipoxygenase-3 (P09186) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09186
Elsewhere: RCSB PDB 1RRH · PDBe 1RRH · UniProt P09186

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