MolNFT v1 · #20711 · protein

X-ray crystal structure of unliganded human ribonuclease 4

1RNF · Protein (ribonuclease 4): “X-ray crystal structure of unliganded human ribonuclease 4”. X-ray diffraction, 2 pockets (best druggability 0.60). MolNFT v1 #20711 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1RNF
Type: protein
Length: 240 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (ribonuclease 4)
EC: 3.1.27.-
UniProt: P34096
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein (ribonuclease 4) (EC 3.1.27.-)	protein	120	26% helix, 33% strand	P34096

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	178	0.60	0.82	33	empty
2	80	0.34	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 634 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

1RNF · X-ray crystal structure of unliganded human ribonuclease 4 · the same entry in another collection · chain A against A, TM-score 1.00
P34096 · AlphaFold monomer V2.0 prediction for ribonuclease 4 (P34096) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P34096
Elsewhere: RCSB PDB 1RNF · PDBe 1RNF · UniProt P34096

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