MolNFT v1 · #2069 · protein + DNA
Multiple antibiotic resistance protein (MARA)/DNA complex
1BL0 · DNA (5'- D(*GP*GP*GP*GP*AP*TP*TP*TP*AP*GP*CP*AP*AP*AP*AP*CP*…: “Multiple antibiotic resistance protein (MARA)/DNA complex”. X-ray diffraction, 4 pockets (best druggability 0.65). MolNFT v1 #2069 on GenesisL1: 3D structure, binding…
- PDB
- 1BL0
- Type
- protein + DNA
- Length
- 164 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*GP*GP*GP*GP*AP*TP*TP*TP*AP*GP*CP*AP*AP*AP*AP*CP*GP*TP*GP *GP*CP*AP*…
- UniProt
- P0ACH5
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 63% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | DNA (5'- D(*GP*GP*GP*GP*AP*TP*TP*TP*AP*GP*CP*AP*AP*AP*AP*CP*GP*TP*GP *GP*CP*AP* TP*C)-3') | dna | 24 | — | — |
| C | DNA (5'- D(*CP*CP*GP*AP*TP*GP*CP*CP*AP*CP*GP*TP*TP*TP*TP*GP*CP*TP*AP *AP*AP*TP* CP*C)-3') | dna | 24 | — | — |
| A | Protein (multiple antibiotic resistance protein) | protein | 116 | 63% helix, 0% strand | P0ACH5 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 201 | 0.65 | 0.84 | 21 | empty |
| 2 | 68 | 0.33 | 0.76 | 13 | empty |
| 3 | 66 | 0.30 | 0.74 | 13 | empty |
| 4 | 60 | 0.26 | 0.73 | 11 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1003 Ų buried · 85 hydrogen bonds · nucleic-nucleic
- B–A · 717 Ų buried · 13 hydrogen bonds · protein-nucleic
- C–A · 637 Ų buried · 12 hydrogen bonds · protein-nucleic
Compared structures
- 1BL0 · Multiple antibiotic resistance protein (MARA)/DNA complex · the same entry in another collection · chain B against B, TM-score 1.00
- P0ACH5 · AlphaFold monomer V2.0 prediction for multiple antibiotic resistance protein mara (P0ACH5) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ACH5
- Elsewhere: RCSB PDB 1BL0 · PDBe 1BL0 · UniProt P0ACH5
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