MolNFT v1 · #20682 · protein

Structures of a monoclonal anti-icam-1 antibody R6.5 fragment at 2.8 ångströms resolution

1RMF · IGG2A-kappa R6.5 Fab (light chain): “Structures of a monoclonal anti-icam-1 antibody R6.5 fragment at 2.8 ångströms resolution”. X-ray diffraction, 6 pockets (best druggability 0.52). MolNFT v1 #20682 on GenesisL1: 3D structure…

PDB: 1RMF
Type: protein
Length: 435 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: IGG2A-kappa R6.5 Fab (light chain); IGG2A-kappa R6.5 Fab (heavy chain)
Pockets: 6 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	IGG2A-kappa R6.5 Fab (light chain)	protein	219	5% helix, 51% strand	—
H	IGG2A-kappa R6.5 Fab (heavy chain)	protein	216	8% helix, 48% strand	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	314	0.52	0.74	45	empty
2	134	0.51	0.79	23	empty
3	74	0.35	0.76	17	empty
4	71	0.34	0.75	16	empty
5	55	0.29	0.75	13	empty

Interfaces

1 interface between chains.

L–H · 1869 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1RMF · Structures of a monoclonal anti-icam-1 antibody R6.5 fragment at 2.8 ångströms resolution · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1RMF · PDBe 1RMF

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