MolNFT v1 · #20580 · protein

Crystal structure of eda-A1

1RJ7 · Ectodysplasin a: “Crystal structure of eda-A1”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #20580 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1RJ7
Type: protein
Length: 1,731 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ectodysplasin a
UniProt: Q92838
Pockets: 20 · best druggability 0.81

Structure

x-ray diffraction · 7 distinct chains · 3% helix, 58% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D, F, G, M	Ectodysplasin a	protein	144	3% helix, 57% strand	Q92838
E	Ectodysplasin a	protein	149	3% helix, 57% strand	Q92838
H	Ectodysplasin a	protein	142	3% helix, 61% strand	Q92838
I	Ectodysplasin a	protein	143	5% helix, 59% strand	Q92838
J	Ectodysplasin a	protein	143	3% helix, 57% strand	Q92838
K	Ectodysplasin a	protein	145	3% helix, 58% strand	Q92838
L	Ectodysplasin a	protein	145	3% helix, 60% strand	Q92838

Pockets

20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	868	0.81	0.83	91	empty
2	1059	0.79	0.81	101	empty
3	579	0.67	0.77	63	empty
4	194	0.65	0.85	23	empty
5	209	0.59	0.81	26	empty

Interfaces

20 interfaces between chains.

K–M · 967 Å² buried · 14 hydrogen bonds · protein-protein
I–J · 950 Å² buried · 17 hydrogen bonds · protein-protein
E–F · 945 Å² buried · 16 hydrogen bonds · protein-protein
H–I · 936 Å² buried · 17 hydrogen bonds · protein-protein
E–G · 935 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

1RJ7 · Crystal structure of EDA-A1 · the same entry in another collection · chain F against F, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92838
Elsewhere: RCSB PDB 1RJ7 · PDBe 1RJ7 · UniProt Q92838

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.