MolNFT v1 · #20538 · protein

Sulfur-substituted rhodanese

1RHS: “Sulfur-substituted rhodanese”. X-ray diffraction, 4 pockets (best druggability 0.50). MolNFT v1 #20538 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1RHS
Type: protein
Length: 293 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sulfur-substituted rhodanese
EC: 2.8.1.1
UniProt: P00586
Pockets: 4 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sulfur-substituted rhodanese (EC 2.8.1.1)	protein	293	33% helix, 15% strand	P00586

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	144	0.50	0.79	24	empty
2	60	0.41	0.81	15	empty
3	63	0.30	0.74	19	empty
4	55	0.25	0.72	17	empty

Modifications

Observed in the structure: 1 modified (oxidation).

Compared structures

1RHS · Sulfur-substituted rhodanese · the same entry in another collection · chain A against A, TM-score 1.00
P00586 · AlphaFold monomer V2.0 prediction for thiosulfate sulfurtransferase (P00586) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00586
Elsewhere: RCSB PDB 1RHS · PDBe 1RHS · UniProt P00586

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