GL1X · GenesisL1 explorer

MolNFT v1 · #20526 · protein

Crystal structure of human TYRO3-D1D2

1RHF · Tyrosine-protein kinase receptor TYRO3: “Crystal structure of human TYRO3-D1D2”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.32). MolNFT v1 #20526 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
1RHF
Type
protein
Length
352 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Tyrosine-protein kinase receptor TYRO3
EC
2.7.1.112
UniProt
Q06418
Ligands
ZN
Pockets
1 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 57% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, BTyrosine-protein kinase receptor TYRO3 (EC 2.7.1.112)protein1762% helix, 57% strandQ06418

Ligands and binding sites

  • ZN · Zinc ion · metal · chains A, B
  • ACT · Acetate ion · additive · 4 copies · chains A, B
  • EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1720.320.7421ACT

Interfaces

1 interface between chains.

  • A–B · 264 Ų buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 4 modified (disulfide, engineered).

Compared structures

  • 1RHF · Crystal Structure of human Tyro3-D1D2 · the same entry in another collection · chain A against A, TM-score 1.00
  • Q06418 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase receptor TYRO3 (Q06418) · a predicted model of the same protein · chain A against A, TM-score 0.90

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