MolNFT v1 · #20509 · protein

Crystal structure of resisitin

1RGX · Resistin: “Crystal structure of resisitin”. X-ray diffraction, 1 pocket (best druggability 0.26). MolNFT v1 #20509 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1RGX
Type: protein
Length: 272 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Resistin
UniProt: Q99P87
Pockets: 1 · best druggability 0.26

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Resistin	protein	89	24% helix, 45% strand	Q99P87
C	Resistin	protein	94	23% helix, 43% strand	Q99P87

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.26	0.73	17	empty

Interfaces

3 interfaces between chains.

B–C · 1053 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 1052 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 1029 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 15 disulfide (disulfide).

Compared structures

1RGX · Crystal Structure of resisitin · the same entry in another collection · chain A against A, TM-score 1.00
Q99P87 · AlphaFold monomer V2.0 prediction for resistin (Q99P87) · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99P87
Elsewhere: RCSB PDB 1RGX · PDBe 1RGX · UniProt Q99P87

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