MolNFT v1 · #20501 · protein

GTPase-activation domain from rhogap

1RGP: “GTPase-activation domain from rhogap”. X-ray diffraction, 2 pockets (best druggability 0.37). MolNFT v1 #20501 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1RGP
Type: protein
Length: 189 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rhogap
UniProt: Q07960
Pockets: 2 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 62% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rhogap	protein	189	62% helix, 0% strand	Q07960

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.37	0.77	23	empty
2	58	0.35	0.78	13	empty

Compared structures

1RGP · GTPase-activation domain from rhogap · the same entry in another collection · chain A against A, TM-score 1.00
Q07960 · AlphaFold monomer V2.0 prediction for rho GTPase-activating protein 1 (Q07960) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07960
Elsewhere: RCSB PDB 1RGP · PDBe 1RGP · UniProt Q07960

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