MolNFT v1 · #20475 · protein

Crystal structure of quorum-sensing antiactivator tram

1RFY · Transcriptional repressor tram: “Crystal structure of quorum-sensing antiactivator tram”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #20475 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1RFY
Type: protein
Length: 177 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional repressor tram
UniProt: Q57471
Pockets: 2 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional repressor tram	protein	89	72% helix, 0% strand	Q57471
B	Transcriptional repressor tram	protein	88	73% helix, 0% strand	Q57471

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	99	0.43	0.78	23	empty
2	50	0.34	0.79	15	empty

Interfaces

1 interface between chains.

A–B · 654 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1RFY · Crystal Structure of Quorum-Sensing Antiactivator TraM · the same entry in another collection · chain A against A, TM-score 1.00
Q57471 · AlphaFold monomer V2.0 prediction for transcriptional repressor tram (Q57471) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q57471
Elsewhere: RCSB PDB 1RFY · PDBe 1RFY · UniProt Q57471

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