MolNFT v1 · #20456 · protein

Anti-cocaine antibody M82G2

1RFD · Fab M82G2, light chain: “Anti-cocaine antibody M82G2”. X-ray diffraction, 6 pockets (best druggability 0.55). MolNFT v1 #20456 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1RFD
Type: protein
Length: 438 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab M82G2, light chain; Fab M82G2, heavy chain
Pockets: 6 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Fab M82G2, light chain	protein	218	6% helix, 50% strand	—
H	Fab M82G2, heavy chain	protein	220	10% helix, 52% strand	—

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	376	0.55	0.74	51	empty
2	123	0.41	0.75	19	empty
3	94	0.39	0.76	19	empty
4	78	0.32	0.74	16	empty
5	57	0.30	0.75	12	empty

Interfaces

1 interface between chains.

L–H · 1705 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1RFD · Anti-cocaine antibody M82G2 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1RFD · PDBe 1RFD

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