MolNFT v1 · #20455 · protein

Crystal structure of recombinant bovine interferon-gamma at 3.0 ångströms resolution

1RFB: “Crystal structure of recombinant bovine interferon-gamma at 3.0 ångströms resolution”. X-ray diffraction, 8 pockets (best druggability 0.73). MolNFT v1 #20455 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1RFB
Type: protein
Length: 238 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interferon-gamma
UniProt: P07353
Pockets: 8 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Interferon-gamma	protein	119	53% helix, 0% strand	P07353

Pockets

8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	412	0.73	0.83	50	empty
2	212	0.70	0.87	34	empty
3	81	0.68	0.93	31	empty
4	59	0.58	0.90	16	empty
5	61	0.55	0.88	21	empty

Interfaces

1 interface between chains.

A–B · 2771 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

1RFB · Crystal structure of recombinant bovine interferon-gamma at 3.0 ångströms resolution · the same entry in another collection · chain A against A, TM-score 1.00
P07353 · AlphaFold monomer V2.0 prediction for interferon gamma (P07353) · a predicted model of the same protein · chain A against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07353
Elsewhere: RCSB PDB 1RFB · PDBe 1RFB · UniProt P07353

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