MolNFT v1 · #20447 · protein
Structurally distinct recognition motifs in lymphotoxin-B receptor and CD40 for traf-mediated signaling
1RF3 · TNF receptor associated factor 3: “Structurally distinct recognition motifs in lymphotoxin-B receptor and CD40 for traf-mediated signaling”. X-ray diffraction, 2 pockets (best druggability 0.34). MolNFT v1 #20447 on GenesisL1: 3D…
- PDB
- 1RF3
- Type
- protein
- Length
- 216 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TNF receptor associated factor 3; 24-residue peptide from lymphotoxin-B receptor
- UniProt
- Q13114, P36941
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TNF receptor associated factor 3 | protein | 192 | 23% helix, 17% strand | Q13114 |
| B | 24-residue peptide from lymphotoxin-B receptor | protein | 24 | 0% helix, 0% strand | P36941 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.34 | 0.74 | 23 | empty |
| 2 | 102 | 0.32 | 0.72 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 665 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1RF3 · Structurally Distinct Recognition Motifs in Lymphotoxin-B Receptor and CD40 for… · the same entry in another collection · chain A against A, TM-score 1.00
- Q13114 · AlphaFold monomer V2.0 prediction for TNF receptor-associated factor 3 (Q13114) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P36941 · AlphaFold monomer V2.0 prediction for tumor necrosis factor receptor superfamily member 3… · a predicted model of the same protein · chain B against A, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13114
- Every structure of UniProt P36941
- Elsewhere: RCSB PDB 1RF3 · PDBe 1RF3 · UniProt Q13114 · UniProt P36941
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