MolNFT v1 · #20321 · protein
Substitution of ASP193 to asn at the active site of ribulose-1,5- bisphosphate carboxylase results in conformational changes
1RBA · Rubisco: “Substitution of ASP193 to asn at the active site of ribulose-1,5- bisphosphate carboxylase results in…”. X-ray diffraction, 7 pockets (best druggability 0.81). MolNFT v1 #20321 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1RBA
- Type
- protein
- Length
- 862 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rubisco
- EC
- 4.1.1.39
- UniProt
- P04718
- Pockets
- 7 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rubisco (EC 4.1.1.39) | protein | 419 | 30% helix, 17% strand | P04718 |
| B | Rubisco (EC 4.1.1.39) | protein | 443 | 32% helix, 15% strand | P04718 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.81 | 0.97 | 34 | empty |
| 2 | 487 | 0.63 | 0.76 | 77 | empty |
| 3 | 374 | 0.60 | 0.77 | 48 | empty |
| 4 | 55 | 0.42 | 0.82 | 14 | empty |
| 5 | 80 | 0.34 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 3476 Ų buried · 59 hydrogen bonds · protein-protein
Compared structures
- 1RBA · Substitution of ASP193 to asn at the active site of ribulose-1,5-bisphosphate carboxylase… · the same entry in another collection · chain A against A, TM-score 1.00
- P04718 · AlphaFold monomer V2.0 prediction for ribulose bisphosphate carboxylase (P04718) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04718
- Elsewhere: RCSB PDB 1RBA · PDBe 1RBA · UniProt P04718
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