MolNFT v1 · #20151 · protein

Connexin 43 carboxyl terminal domain

1R5S · Gap junction alpha-1 protein: “Connexin 43 carboxyl terminal domain”. Solution nmr, 1 pocket (best druggability 0.32). MolNFT v1 #20151 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1R5S
Type: protein
Length: 132 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gap junction alpha-1 protein
UniProt: P08050
Pockets: 1 · best druggability 0.32

Structure

solution nmr · 1 distinct chain · 12% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gap junction alpha-1 protein	protein	132	12% helix, 0% strand	P08050

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	80	0.32	0.74	21	empty

Compared structures

1R5S · Connexin 43 Carboxyl Terminal Domain · the same entry in another collection · chain A against A, TM-score 1.00
P08050 · AlphaFold monomer V2.0 prediction for gap junction alpha-1 protein (P08050) · a predicted model of the same protein · chain A against A, TM-score 0.29

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08050
Elsewhere: RCSB PDB 1R5S · PDBe 1R5S · UniProt P08050

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