MolNFT v1 · #20081 · protein

Uroporphyrinogen decarboxylase in complex with coproporphyrinogen-I

1R3Q: “Uroporphyrinogen decarboxylase in complex with coproporphyrinogen-I”. X-ray diffraction, 2 ligands (1CP, CO2), 2 pockets (best druggability 0.69). MolNFT v1 #20081 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1R3Q
Type: protein
Length: 357 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uroporphyrinogen decarboxylase
EC: 4.1.1.37
UniProt: P06132
Ligands: 1CP, CO2
Pockets: 2 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uroporphyrinogen decarboxylase (EC 4.1.1.37)	protein	357	53% helix, 11% strand	P06132

Ligands and binding sites

1CP · Coproporphyrinogen I · ligand · chains A
CO2 · Carbon dioxide · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	501	0.69	0.79	40	1CP, CO2
2	52	0.26	0.73	13	empty

Compared structures

1R3Q · Uroporphyrinogen Decarboxylase in complex with coproporphyrinogen-I · the same entry in another collection · chain A against A, TM-score 1.00
P06132 · AlphaFold monomer V2.0 prediction for uroporphyrinogen decarboxylase (P06132) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06132
Elsewhere: RCSB PDB 1R3Q · PDBe 1R3Q · UniProt P06132

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