MolNFT v1 · #19943 · protein + DNA
Crystal structure of POT1 (protection of telomere)- ssdna complex
1QZG · Telomeric single-stranded DNA: “Crystal structure of POT1 (protection of telomere)- ssdna complex”. X-ray diffraction, 1 ligand (TMP), 3 pockets (best druggability 0.62). MolNFT v1 #19943 on GenesisL1: 3D structure, binding sites…
- PDB
- 1QZG
- Type
- protein + DNA
- Length
- 350 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomeric single-stranded DNA; Protection of telomeres protein 1
- UniProt
- O13988
- Ligands
- TMP
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, D | Telomeric single-stranded DNA | dna | 5 | — | — |
| A, B | Protection of telomeres protein 1 | protein | 170 | 18% helix, 39% strand | O13988 |
Ligands and binding sites
- TMP · Thymidine-5'-phosphate · ligand · 2 copies · chains C, A, D, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 256 | 0.62 | 0.80 | 37 | empty |
| 2 | 340 | 0.53 | 0.74 | 36 | empty |
| 3 | 57 | 0.29 | 0.75 | 12 | empty |
Interfaces
3 interfaces between chains.
- C–A · 584 Ų buried · 18 hydrogen bonds · protein-nucleic
- D–B · 577 Ų buried · 15 hydrogen bonds · protein-nucleic
- A–B · 417 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1QZG · Crystal structure of Pot1 (protection of telomere)- ssDNA complex · the same entry in another collection · chain C against C, TM-score 1.00
- O13988 · AlphaFold monomer V2.0 prediction for protection of telomeres protein 1 (O13988) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O13988
- Elsewhere: RCSB PDB 1QZG · PDBe 1QZG · UniProt O13988
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.