MolNFT v1 · #19918 · protein

2.1 ångström crystal structure of ksga: a universally conserved adenosine dimethyltransferase

1QYR · High level kasugamycin resistance protein: “2.1 ångström crystal structure of ksga: a universally conserved adenosine dimethyltransferase”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #19918 on GenesisL1: 3D…

PDB: 1QYR
Type: protein
Length: 504 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: High level kasugamycin resistance protein
EC: 2.1.1.-
UniProt: P06992
Pockets: 3 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	High level kasugamycin resistance protein (EC 2.1.1.-)	protein	252	44% helix, 20% strand	P06992

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	192	0.63	0.83	36	empty
2	236	0.62	0.81	37	empty
3	96	0.38	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 316 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1QYR · 2.1 Angstrom Crystal structure of KsgA: A Universally Conserved Adenosine… · the same entry in another collection · chain A against A, TM-score 1.00
P06992 · AlphaFold monomer V2.0 prediction for ribosomal RNA small subunit methyltransferase a… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06992
Elsewhere: RCSB PDB 1QYR · PDBe 1QYR · UniProt P06992

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