MolNFT v1 · #19856 · protein
Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain
1QWT · Interferon regulatory factor 3: “Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain”. X-ray diffraction, 1 ligand (PO4), 2 pockets (best druggability 0.53). MolNFT v1 #19856 on GenesisL1: 3D structure…
- PDB
- 1QWT
- Type
- protein
- Length
- 478 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon regulatory factor 3
- UniProt
- Q14653
- Ligands
- PO4
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Interferon regulatory factor 3 | protein | 239 | 25% helix, 29% strand | Q14653 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 281 | 0.53 | 0.75 | 39 | empty |
| 2 | 66 | 0.29 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 494 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1QWT · Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q14653 · AlphaFold monomer V2.0 prediction for interferon regulatory factor 3 (Q14653) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14653
- Elsewhere: RCSB PDB 1QWT · PDBe 1QWT · UniProt Q14653
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