MolNFT v1 · #19826 · protein
Crystal structure of rhogdi K(199,200)R double mutant
1QVY · Rho GDP-dissociation inhibitor 1: “Crystal structure of rhogdi K(199,200)R double mutant”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.74). MolNFT v1 #19826 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1QVY
- Type
- protein
- Length
- 552 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho GDP-dissociation inhibitor 1
- UniProt
- P52565
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 7% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Rho GDP-dissociation inhibitor 1 | protein | 138 | 7% helix, 57% strand | P52565 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1032 | 0.74 | 0.77 | 84 | SO4 |
| 2 | 66 | 0.47 | 0.83 | 20 | empty |
Interfaces
4 interfaces between chains.
- A–B · 697 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 684 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 129 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 69 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52565
- Elsewhere: RCSB PDB 1QVY · PDBe 1QVY · UniProt P52565
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