MolNFT v1 · #19718 · protein

N-terminally truncated C3DG fragment

1QSJ · Complement C3 precursor: “N-terminally truncated C3DG fragment”. X-ray diffraction, 10 pockets (best druggability 0.73). MolNFT v1 #19718 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1QSJ
Type: protein
Length: 1,104 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Complement C3 precursor
UniProt: P01026
Pockets: 10 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Complement C3 precursor	protein	276	64% helix, 2% strand	P01026

Pockets

10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	199	0.73	0.89	34	empty
2	418	0.71	0.82	47	empty
3	451	0.71	0.81	48	empty
4	162	0.70	0.89	28	empty
5	534	0.67	0.78	52	empty

Interfaces

3 interfaces between chains.

C–D · 1515 Å² buried · 22 hydrogen bonds · protein-protein
A–B · 1505 Å² buried · 19 hydrogen bonds · protein-protein
A–C · 631 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1QSJ · N-terminally truncated C3DG fragment · the same entry in another collection · chain D against D, TM-score 1.00
P01026 · AlphaFold monomer V2.0 prediction for complement C3 (P01026) · a predicted model of the same protein · chain B against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01026
Elsewhere: RCSB PDB 1QSJ · PDBe 1QSJ · UniProt P01026

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