MolNFT v1 · #19598 · protein

Kappa variable light chain

1QP1 · Bence-jones kappa I antibody bre (light chain): “Kappa variable light chain”. X-ray diffraction, 3 pockets (best druggability 0.44). MolNFT v1 #19598 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1QP1
Type: protein
Length: 321 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bence-jones kappa I antibody bre (light chain)
Pockets: 3 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Bence-jones kappa I antibody bre (light chain)	protein	107	3% helix, 50% strand	—

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	146	0.44	0.76	29	empty
2	100	0.35	0.74	26	empty
3	79	0.33	0.74	16	empty

Interfaces

2 interfaces between chains.

B–C · 732 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 655 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

1QP1 · Kappa variable light chain · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1QP1 · PDBe 1QP1

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