MolNFT v1 · #19597 · protein + DNA
Purine repressor-hypoxanthine-palindromic operator complex
1QP0 · DNA (5'- D(*TP*AP*CP*GP*CP*AP*AP*CP*CP*GP*GP*TP*TP*GP*CP*GP*…: “Purine repressor-hypoxanthine-palindromic operator complex”. X-ray diffraction, 1 ligand (HPA), 3 pockets (best druggability 0.65). MolNFT v1 #19597 on GenesisL1: 3D…
- PDB
- 1QP0
- Type
- protein + DNA
- Length
- 355 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*TP*AP*CP*GP*CP*AP*AP*CP*CP*GP*GP*TP*TP*GP*CP*GP*T)-3'); Protein (purine…
- UniProt
- P0ACP7
- Ligands
- HPA
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | DNA (5'- D(*TP*AP*CP*GP*CP*AP*AP*CP*CP*GP*GP*TP*TP*GP*CP*GP*T)-3') | dna | 17 | — | — |
| A | Protein (purine nucleotide synthesis repressor) | protein | 338 | 44% helix, 15% strand | P0ACP7 |
Ligands and binding sites
- HPA · Hypoxanthine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.65 | 0.87 | 30 | HPA |
| 2 | 171 | 0.42 | 0.73 | 25 | empty |
| 3 | 169 | 0.40 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- M–A · 509 Ų buried · 11 hydrogen bonds · protein-nucleic
Compared structures
- 1QP0 · Purine repressor-hypoxanthine-palindromic operator complex · the same entry in another collection · chain A against A, TM-score 1.00
- P0ACP7 · AlphaFold monomer V2.0 prediction for hth-type transcriptional repressor purr (P0ACP7) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ACP7
- Elsewhere: RCSB PDB 1QP0 · PDBe 1QP0 · UniProt P0ACP7
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