MolNFT v1 · #19566 · protein
Crystal structure of N-((5'-phosphoribosyl)-formimino)-5- aminoimidazol-4-carboxamid ribonucleotid isomerase (ec 3.1.3.15, hisa)
1QO2: “Crystal structure of N-((5'-phosphoribosyl)-formimino)-5- aminoimidazol-4-carboxamid ribonucleotid isomerase…”. X-ray diffraction, 5 pockets (best druggability 0.77). MolNFT v1 #19566 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1QO2
- Type
- protein
- Length
- 482 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- EC
- 5.3.1.15
- UniProt
- Q9X0C7
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | (EC 5.3.1.15) | protein | 241 | 43% helix, 24% strand | Q9X0C7 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 669 | 0.77 | 0.83 | 53 | empty |
| 2 | 798 | 0.76 | 0.80 | 56 | empty |
| 3 | 170 | 0.51 | 0.78 | 21 | empty |
| 4 | 151 | 0.50 | 0.78 | 24 | empty |
| 5 | 124 | 0.44 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 705 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 1QO2 · Crystal structure of N-((5'-phosphoribosyl)-formimino)-5-aminoimidazol-4-carboxamid… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9X0C7 · AlphaFold monomer V2.0 prediction for 1-(5-phosphoribosyl)-5-[(5-PHOSPHORIBOSYLAMINO)METHY… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X0C7
- Elsewhere: RCSB PDB 1QO2 · PDBe 1QO2 · UniProt Q9X0C7
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