MolNFT v1 · #19505 · protein

Nuclear transport factor 2 (NTF2) W7A mutant

1QMA: “Nuclear transport factor 2 (NTF2) W7A mutant”. X-ray diffraction, 9 pockets (best druggability 0.54). MolNFT v1 #19505 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1QMA
Type: protein
Length: 500 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear transport factor 2
UniProt: P13662
Pockets: 9 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Nuclear transport factor 2	protein	126	29% helix, 45% strand	P13662
B, D	Nuclear transport factor 2	protein	124	24% helix, 48% strand	P13662

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	213	0.54	0.78	29	empty
2	224	0.53	0.77	29	empty
3	226	0.51	0.76	42	empty
4	80	0.46	0.81	23	empty
5	142	0.44	0.76	24	empty

Interfaces

6 interfaces between chains.

A–B · 1373 Å² buried · 20 hydrogen bonds · protein-protein
C–D · 1373 Å² buried · 21 hydrogen bonds · protein-protein
A–C · 333 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 124 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 122 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1QMA · Nuclear Transport Factor 2 (NTF2) W7A mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13662
Elsewhere: RCSB PDB 1QMA · PDBe 1QMA · UniProt P13662

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.