MolNFT v1 · #19495 · protein

Human prion protein fragment 90-230

1QM0: “Human prion protein fragment 90-230”. Solution nmr, 1 pocket (best druggability 0.38). MolNFT v1 #19495 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1QM0
Type: protein
Length: 104 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prion protein
UniProt: P04156
Pockets: 1 · best druggability 0.38

Structure

solution nmr · 1 distinct chain · 54% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prion protein	protein	104	54% helix, 4% strand	P04156

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.38	0.81	14	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1QM0 · Human prion protein fragment 90-230 · the same entry in another collection · chain A against A, TM-score 1.00
P04156 · AlphaFold monomer V2.0 prediction for major prion protein (P04156) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04156
Elsewhere: RCSB PDB 1QM0 · PDBe 1QM0 · UniProt P04156

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