MolNFT v1 · #19349 · protein

DNA polymerase from thermococcus sp. 9ON-7 archaeon

1QHT · Protein (DNA polymerase): “DNA polymerase from thermococcus sp. 9ON-7 archaeon”. X-ray diffraction, 10 pockets (best druggability 0.69). MolNFT v1 #19349 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1QHT
Type: protein
Length: 710 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (DNA polymerase)
EC: 2.7.7.7
UniProt: Q56366
Pockets: 10 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (DNA polymerase) (EC 2.7.7.7)	protein	710	40% helix, 23% strand	Q56366

Pockets

10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	583	0.69	0.78	48	empty
2	431	0.66	0.78	49	empty
3	477	0.59	0.74	63	empty
4	219	0.56	0.78	20	empty
5	208	0.47	0.74	22	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1QHT · DNA polymerase from thermococcus sp. 9ON-7 archaeon · the same entry in another collection · chain A against A, TM-score 1.00
Q56366 · AlphaFold monomer V2.0 prediction for DNA polymerase (Q56366) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q56366
Elsewhere: RCSB PDB 1QHT · PDBe 1QHT · UniProt Q56366

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