MolNFT v1 · #191463 · protein
Crystal structure of human eukaryotic translation initiation factor 2A (EIF2A)
8DYS: “Crystal structure of human eukaryotic translation initiation factor 2A (EIF2A)”. X-ray diffraction, 1 ligand (UNX), 1 pocket (best druggability 0.68). MolNFT v1 #191463 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8DYS
- Type
- protein
- Length
- 409 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 2A
- UniProt
- Q9BY44
- Ligands
- UNX
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 1% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 2A | protein | 409 | 1% helix, 46% strand | Q9BY44 |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 3 copies · chains A
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 869 | 0.68 | 0.74 | 73 | EDO, UNX |
Compared structures
- 8DYS · Crystal structure of human Eukaryotic translation initiation factor 2A (eIF2A) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BY44 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 2A (Q9BY44) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BY44
- Elsewhere: RCSB PDB 8DYS · PDBe 8DYS · UniProt Q9BY44
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