MolNFT v1 · #19144 · protein
Human CDC25B catalytic domain
1QB0 · Protein (M-phase inducer phosphatase 2 (CDC25B)): “Human CDC25B catalytic domain”. X-ray diffraction, 2 ligands (SO4, CL), 3 pockets (best druggability 0.54). MolNFT v1 #19144 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1QB0
- Type
- protein
- Length
- 177 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (M-phase inducer phosphatase 2 (CDC25B))
- EC
- 3.1.3.48
- UniProt
- P30305
- Ligands
- SO4, CL
- Pockets
- 3 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (M-phase inducer phosphatase 2 (CDC25B)) (EC 3.1.3.48) | protein | 177 | 32% helix, 17% strand | P30305 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- BME · Beta-mercaptoethanol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 153 | 0.54 | 0.80 | 22 | SO4, CL |
| 2 | 107 | 0.47 | 0.79 | 18 | BME |
| 3 | 63 | 0.32 | 0.76 | 18 | empty |
Modifications
Observed in the structure: 2 covalent (additive adduct).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30305
- Elsewhere: RCSB PDB 1QB0 · PDBe 1QB0 · UniProt P30305
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