MolNFT v1 · #191140 · protein

Crystal structure of poplar glutathione transferase U20 in complex with glutathionylphenylacetophenone

8A0I: “Crystal structure of poplar glutathione transferase U20 in complex with glutathionylphenylacetophenone”. X-ray diffraction, 1 ligand (CNZ), 3 pockets (best druggability 0.56). MolNFT v1 #191140 on GenesisL1: 3D structure, binding…

PDB: 8A0I
Type: protein
Length: 215 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutathione transferase
EC: 2.5.1.18
UniProt: D2X9R3
Ligands: CNZ
Pockets: 3 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 60% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutathione transferase (EC 2.5.1.18)	protein	215	60% helix, 9% strand	D2X9R3

Ligands and binding sites

CNZ · L-gamma-glutamyl-S-(2-biphenyl-4-yl-2-oxoethyl)-L-cysteinylglycine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	233	0.56	0.77	25	CNZ
2	73	0.35	0.76	12	empty
3	67	0.32	0.75	18	empty

Compared structures

8A0I · Crystal structure of poplar glutathione transferase U20 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D2X9R3
Elsewhere: RCSB PDB 8A0I · PDBe 8A0I · UniProt D2X9R3

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