MolNFT v1 · #191109 · protein
Crystal structure of the native zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 1.80 a resolution.
7ZVA · C-terminal peptidase: “Crystal structure of the native zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 1.80 a…”. X-ray diffraction, 2 ligands (NAG, FUC), 2 pockets (best druggability 0.55). MolNFT v1 #191109 on…
- PDB
- 7ZVA
- Type
- protein
- Length
- 335 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- C-terminal peptidase
- Ligands
- NAG, FUC
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | C-terminal peptidase | protein | 335 | 9% helix, 37% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A
- FUC · alpha-L-fucopyranose · sugar · chains A
- ACT · Acetate ion · additive · 8 copies · chains A
- GOL · Glycerol · additive · 5 copies · chains A
- IPA · Isopropyl alcohol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 156 | 0.55 | 0.81 | 38 | GOL |
| 2 | 60 | 0.32 | 0.76 | 12 | GOL |
Modifications
Observed in the structure: 3 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 7ZVA · Crystal Structure of the native zymogen form of the glutamic-class prolyl-endopeptidase… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7ZVA · PDBe 7ZVA
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.