MolNFT v1 · #191028 · protein

Crystal structure of amycolatopsis jejuensis multiple inositol polyphosphate phosphatase, apo-protein

7ZGF · Multiple inositol-polyphosphate phosphatase: “Crystal structure of amycolatopsis jejuensis multiple inositol polyphosphate phosphatase, apo-protein”. X-ray diffraction, 8 pockets (best druggability 0.70). MolNFT v1 #191028 on…

PDB: 7ZGF
Type: protein
Length: 823 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multiple inositol-polyphosphate phosphatase
EC: 3.1.3.62
Pockets: 8 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 52% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Multiple inositol-polyphosphate phosphatase (EC 3.1.3.62)	protein	413	51% helix, 13% strand	—
B	Multiple inositol-polyphosphate phosphatase (EC 3.1.3.62)	protein	410	52% helix, 13% strand	—

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	470	0.70	0.80	56	empty
2	369	0.67	0.81	42	empty
3	368	0.58	0.75	44	empty
4	304	0.57	0.76	45	empty
5	115	0.43	0.77	24	empty

Interfaces

1 interface between chains.

A–B · 737 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

7ZGF · Crystal Structure of Amycolatopsis jejuensis Multiple Inositol Polyphosphate Phosphatase… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7ZGF · PDBe 7ZGF

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