MolNFT v1 · #190960 · protein
Gstf SH101 mutant
7ZA5 · Glutathione transferase: “Gstf SH101 mutant”. X-ray diffraction, 3 pockets (best druggability 0.48). MolNFT v1 #190960 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7ZA5
- Type
- protein
- Length
- 401 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione transferase
- EC
- 2.5.1.18
- UniProt
- Q9ZS17
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Glutathione transferase (EC 2.5.1.18) | protein | 202 | 59% helix, 9% strand | Q9ZS17 |
| A | Glutathione transferase (EC 2.5.1.18) | protein | 199 | 58% helix, 8% strand | Q9ZS17 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 215 | 0.48 | 0.75 | 28 | empty |
| 2 | 112 | 0.39 | 0.75 | 18 | empty |
| 3 | 110 | 0.37 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- B–A · 1115 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7ZA5 · GSTF sh101 mutant · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ZS17
- Elsewhere: RCSB PDB 7ZA5 · PDBe 7ZA5 · UniProt Q9ZS17
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