MolNFT v1 · #190956 · DNA

Phen-DC3 intercalation causes hybrid-to-antiparallel transformation of human telomeric DNA G-quadruplex

7Z9L · DNA (5'- D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*…: “Phen-DC3 intercalation causes hybrid-to-antiparallel transformation of human telomeric DNA G-quadruplex”. Solution nmr, 1 ligand (PQ3), 1 pocket (best druggability…

PDB: 7Z9L
Type: DNA
Length: 23 nucleotides
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'- D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP* G)-3')
Ligands: PQ3
Pockets: 1 · best druggability 0.51

Structure

solution nmr · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA (5'- D(TPAPGPGPGPTPTPAPGPGPGPTPTPAPGPGPGPTPTPAPGPGP* G)-3')	dna	23	—	—

Ligands and binding sites

PQ3 · N2,N9-bis(1-methylquinolin-3-yl)-1,10-phenanthroline-2, 9-dicarboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.51	0.81	10	PQ3

Compared structures

7Z9L · Phen-DC3 intercalation causes hybrid-to-antiparallel transformation of human telomeric… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7Z9L · PDBe 7Z9L

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