MolNFT v1 · #19095 · protein
RNase T1 variant with adenine specificity
1Q9E · Guanyl-specific ribonuclease T1 precursor: “RNase T1 variant with adenine specificity”. X-ray diffraction, 2 pockets (best druggability 0.36). MolNFT v1 #19095 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1Q9E
- Type
- protein
- Length
- 312 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanyl-specific ribonuclease T1 precursor
- EC
- 3.1.27.3
- UniProt
- P00651
- Pockets
- 2 · best druggability 0.36
Structure
x-ray diffraction · 1 distinct chain · 16% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Guanyl-specific ribonuclease T1 precursor (EC 3.1.27.3) | protein | 104 | 16% helix, 31% strand | P00651 |
Ligands and binding sites
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.36 | 0.78 | 19 | empty |
| 2 | 61 | 0.28 | 0.73 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–C · 190 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 22 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00651
- Elsewhere: RCSB PDB 1Q9E · PDBe 1Q9E · UniProt P00651
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.