MolNFT v1 · #190534 · protein

Structure of MTRPV2_Q525F

7XEW · Transient receptor potential cation channel subfamily V…: “Structure of MTRPV2_Q525F”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #190534 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7XEW
Type: protein
Length: 2,456 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily V member 2
UniProt: Q9WTR1
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 1 distinct chain · 55% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily V member 2	protein	614	55% helix, 5% strand	Q9WTR1

Pockets

20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	671	0.82	0.86	70	empty
2	437	0.82	0.89	36	empty
3	567	0.81	0.87	49	empty
4	454	0.81	0.88	41	empty
5	445	0.81	0.88	39	empty

Interfaces

6 interfaces between chains.

B–C · 2684 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 2683 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 2683 Å² buried · 11 hydrogen bonds · protein-protein
A–D · 2680 Å² buried · 11 hydrogen bonds · protein-protein
B–D · 27 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7XEW · Structure of mTRPV2_Q525F · the same entry in another collection · chain A against A, TM-score 1.00
Q9WTR1 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WTR1
Elsewhere: RCSB PDB 7XEW · PDBe 7XEW · UniProt Q9WTR1

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