MolNFT v1 · #190514 · protein

Crystal structure of human rptph

7XC0 · Receptor-type tyrosine-protein phosphatase H: “Crystal structure of human rptph”. X-ray diffraction, 1 ligand (PO4), 3 pockets (best druggability 0.36). MolNFT v1 #190514 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7XC0
Type: protein
Length: 287 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-type tyrosine-protein phosphatase H
EC: 3.1.3.48
UniProt: Q9HD43
Ligands: PO4
Pockets: 3 · best druggability 0.36

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase H (EC 3.1.3.48)	protein	287	38% helix, 21% strand	Q9HD43

Ligands and binding sites

PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.36	0.77	18	empty
2	75	0.32	0.75	18	empty
3	51	0.28	0.75	11	empty

Compared structures

7XC0 · Crystal structure of Human RPTPH · the same entry in another collection · chain A against A, TM-score 1.00
Q9HD43 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase H… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HD43
Elsewhere: RCSB PDB 7XC0 · PDBe 7XC0 · UniProt Q9HD43

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