MolNFT v1 · #190507 · protein
CVB5-intermediate altered particle containing VP1/VP2/VP3 and RNA genome
7XB2 · Genome polyprotein: “CVB5-intermediate altered particle containing VP1/VP2/VP3 and RNA genome”. Electron microscopy, 8 pockets (best druggability 0.52). MolNFT v1 #190507 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7XB2
- Type
- protein
- Length
- 712 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Genome polyprotein
- EC
- 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- A0A348FI90, A0A6M4MJ36
- Pockets
- 8 · best druggability 0.52
Structure
electron microscopy · 3 distinct chains · 9% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1 | Genome polyprotein | protein | 233 | 7% helix, 31% strand | A0A348FI90 |
| 2 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 248 | 9% helix, 41% strand | A0A6M4MJ36 |
| 3 | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 231 | 10% helix, 29% strand | A0A6M4MJ36 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 156 | 0.52 | 0.80 | 25 | empty |
| 2 | 174 | 0.46 | 0.75 | 31 | empty |
| 3 | 62 | 0.42 | 0.81 | 21 | empty |
| 4 | 83 | 0.41 | 0.79 | 21 | empty |
| 5 | 84 | 0.38 | 0.77 | 20 | empty |
Interfaces
3 interfaces between chains.
- 1–3 · 3887 Ų buried · 59 hydrogen bonds · protein-protein
- 1–2 · 1892 Ų buried · 27 hydrogen bonds · protein-protein
- 2–3 · 1569 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 7XB2 · CVB5-intermediate altered particle containing VP1/VP2/VP3 and RNA genome · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A348FI90
- Every structure of UniProt A0A6M4MJ36
- Elsewhere: RCSB PDB 7XB2 · PDBe 7XB2 · UniProt A0A348FI90 · UniProt A0A6M4MJ36
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