MolNFT v1 · #190473 · protein

Crystal structure of a ktsc family protein from euryarchaeon methanolobus vulcani

7X8C · Ktsc domain-containing protein: “Crystal structure of a ktsc family protein from euryarchaeon methanolobus vulcani”. X-ray diffraction, 1 ligand (NA), 2 pockets (best druggability 0.54). MolNFT v1 #190473 on GenesisL1: 3D structure…

PDB: 7X8C
Type: protein
Length: 278 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ktsc domain-containing protein
UniProt: A0A7Z7AYG0
Ligands: NA
Pockets: 2 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Ktsc domain-containing protein	protein	69	23% helix, 33% strand	A0A7Z7AYG0
B, C	Ktsc domain-containing protein	protein	70	24% helix, 31% strand	A0A7Z7AYG0

Ligands and binding sites

NA · Sodium ion · metal · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	121	0.54	0.82	18	empty
2	154	0.48	0.77	24	empty

Interfaces

5 interfaces between chains.

C–D · 642 Å² buried · 8 hydrogen bonds · protein-protein
B–D · 312 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 245 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 231 Å² buried · 1 hydrogen bond · protein-protein
A–B · 165 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

7X8C · Crystal structure of a KTSC family protein from Euryarchaeon Methanolobus vulcani · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A7Z7AYG0
Elsewhere: RCSB PDB 7X8C · PDBe 7X8C · UniProt A0A7Z7AYG0

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