MolNFT v1 · #190423 · protein
Cryo-EM structure of rac in the state C2 rnc-rac complex
7X3K · Zuotin: “Cryo-EM structure of rac in the state C2 rnc-rac complex”. Electron microscopy, 11 pockets (best druggability 0.78). MolNFT v1 #190423 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7X3K
- Type
- protein
- Length
- 768 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zuotin; Ribosome-associated complex subunit SSZ1
- UniProt
- P32527, P38788
- Pockets
- 11 · best druggability 0.78
Structure
electron microscopy · 2 distinct chains · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Zuotin | protein | 262 | 47% helix, 2% strand | P32527 |
| B | Ribosome-associated complex subunit SSZ1 | protein | 506 | 33% helix, 36% strand | P38788 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 501 | 0.78 | 0.85 | 64 | empty |
| 2 | 743 | 0.73 | 0.79 | 78 | empty |
| 3 | 62 | 0.66 | 0.94 | 16 | empty |
| 4 | 459 | 0.64 | 0.77 | 54 | empty |
| 5 | 138 | 0.57 | 0.83 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 2773 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 7X3K · Cryo-EM structure of RAC in the State C2 RNC-RAC complex · the same entry in another collection · chain B against B, TM-score 1.00
- P38788 · AlphaFold monomer V2.0 prediction for ribosome-associated complex subunit SSZ1 (P38788) · a predicted model of the same protein · chain B against A, TM-score 0.97
- P32527 · AlphaFold monomer V2.0 prediction for zuotin (P32527) · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32527
- Every structure of UniProt P38788
- Elsewhere: RCSB PDB 7X3K · PDBe 7X3K · UniProt P32527 · UniProt P38788
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