MolNFT v1 · #190421 · protein

Structure of CIZ1 bound erh

7X39 · Enhancer of rudimentary HOMOLOG,CIP1-interacting zinc…: “Structure of CIZ1 bound erh”. X-ray diffraction, 4 pockets (best druggability 0.69). MolNFT v1 #190421 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7X39
Type: protein
Length: 479 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Enhancer of rudimentary HOMOLOG,CIP1-interacting zinc finger protein
UniProt: P84090, Q9ULV3
Pockets: 4 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Enhancer of rudimentary HOMOLOG,CIP1-interacting zinc finger protein	protein	128	38% helix, 33% strand	P84090, Q9ULV3
B, C, D	Enhancer of rudimentary HOMOLOG,CIP1-interacting zinc finger protein	protein	117	41% helix, 33% strand	P84090, Q9ULV3

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	682	0.69	0.77	57	empty
2	150	0.40	0.73	20	empty
3	71	0.31	0.74	17	empty
4	53	0.29	0.75	14	empty

Interfaces

4 interfaces between chains.

C–D · 758 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 746 Å² buried · 10 hydrogen bonds · protein-protein
A–D · 349 Å² buried · 4 hydrogen bonds · protein-protein
B–D · 85 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

7X39 · Structure of CIZ1 bound ERH · the same entry in another collection · chain A against A, TM-score 1.00
P84090 · AlphaFold monomer V2.0 prediction for enhancer of rudimentary homolog (P84090) · a predicted model of the same protein · chain D against A, TM-score 0.83
Q9ULV3 · AlphaFold monomer V2.0 prediction for CIP1-interacting zinc finger protein (Q9ULV3) · a predicted model of the same protein · chain A against A, TM-score 0.25

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P84090
Every structure of UniProt Q9ULV3
Elsewhere: RCSB PDB 7X39 · PDBe 7X39 · UniProt P84090 · UniProt Q9ULV3

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