MolNFT v1 · #190420 · protein + RNA

Cryo-EM structure of rnc-rac complex in presence of ssb from S. cerevisiae 2

7X34 · Zuotin: “Cryo-EM structure of rnc-rac complex in presence of ssb from S. cerevisiae 2”. Electron microscopy, 1 pocket (best druggability 0.62). MolNFT v1 #190420 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7X34
Type: protein + RNA
Length: 194 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zuotin; RNA (130-mer)
UniProt: P32527
Pockets: 1 · best druggability 0.62

Structure

electron microscopy · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Zuotin	protein	100	70% helix, 0% strand	P32527
3	RNA (130-mer)	rna	94	—	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	519	0.62	0.76	33	empty

Interfaces

1 interface between chains.

C–3 · 425 Å² buried · 4 hydrogen bonds · protein-nucleic

Compared structures

7X34 · Cryo-EM structure of RNC-RAC complex in presence of Ssb from S. cerevisiae 2 · the same entry in another collection · chain C against C, TM-score 1.00
P32527 · AlphaFold monomer V2.0 prediction for zuotin (P32527) · a predicted model of the same protein · chain C against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32527
Elsewhere: RCSB PDB 7X34 · PDBe 7X34 · UniProt P32527

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