MolNFT v1 · #190419 · DNA

NMR solution structure of the 1:1 complex of a pyridostatin derivative (pypds) bound to a G-quadruplex MYT1L

7X2Z · G-quadruplex DNA MYT1L: “NMR solution structure of the 1:1 complex of a pyridostatin derivative (pypds) bound to a G-quadruplex MYT1L”. Solution nmr, 1 ligand (7U0), 1 pocket (best druggability 0.26). MolNFT v1 #190419 on GenesisL1…

PDB: 7X2Z
Type: DNA
Length: 29 nucleotides
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: G-quadruplex DNA MYT1L
Ligands: 7U0
Pockets: 1 · best druggability 0.26

Structure

solution nmr · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	G-quadruplex DNA MYT1L	dna	29	—	—

Ligands and binding sites

7U0 · 4-(2-azanylethoxy)-N2,N6-bis[4-(2-pyrrolidin-1-ylethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.26	0.73	6	7U0

Compared structures

7X2Z · NMR solution structure of the 1:1 complex of a pyridostatin derivative (PyPDS) bound to a… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7X2Z · PDBe 7X2Z

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.