Structure of USH1C PDZ2 and coiled-coil in complex with CDHR2 C- terminal tail

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 19% strand (DSSP).

Ligands and binding sites

• GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 471 Ų buried · 11 hydrogen bonds · protein-protein

Compared structures

• 7X2E · Structure of USH1C PDZ2 and coiled-coil in complex with CDHR2 C-terminal tail · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y6N9 · AlphaFold monomer V2.0 prediction for harmonin (Q9Y6N9) · a predicted model of the same protein · chain A against A, TM-score 0.74
• E9Q7P9 · AlphaFold monomer V2.0 prediction for cadherin-related family member 2 (E9Q7P9) · a predicted model of the same protein · chain B against A, TM-score 0.47

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y6N9
• Every structure of UniProt E9Q7P9
• Elsewhere: RCSB PDB 7X2E · PDBe 7X2E · UniProt Q9Y6N9 · UniProt E9Q7P9