MolNFT v1 · #190393 · protein
SARS-cov-2 omicron spike trimer
7WZ1 · Spike glycoprotein: “SARS-cov-2 omicron spike trimer”. Electron microscopy, 1 ligand (NAG), 20 pockets (best druggability 0.83). MolNFT v1 #190393 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7WZ1
- Type
- protein
- Length
- 3,092 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spike glycoprotein
- UniProt
- P0DTC2
- Ligands
- NAG
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 3 distinct chains · 19% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spike glycoprotein | protein | 1032 | 20% helix, 24% strand | P0DTC2 |
| B | Spike glycoprotein | protein | 1027 | 19% helix, 23% strand | P0DTC2 |
| C | Spike glycoprotein | protein | 1033 | 19% helix, 24% strand | P0DTC2 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 28 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 848 | 0.83 | 0.85 | 99 | empty |
| 2 | 1175 | 0.82 | 0.83 | 99 | empty |
| 3 | 221 | 0.82 | 0.95 | 30 | empty |
| 4 | 541 | 0.81 | 0.87 | 69 | empty |
| 5 | 595 | 0.79 | 0.85 | 76 | empty |
Interfaces
3 interfaces between chains.
- A–C · 5432 Ų buried · 55 hydrogen bonds · protein-protein
- B–C · 5166 Ų buried · 58 hydrogen bonds · protein-protein
- A–B · 4619 Ų buried · 36 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 39 disulfide, 28 glycan (disulfide, N-glycosylation).
Compared structures
- 7WZ1 · SARS-CoV-2 Omicron Spike trimer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTC2
- Elsewhere: RCSB PDB 7WZ1 · PDBe 7WZ1 · UniProt P0DTC2
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