MolNFT v1 · #190370 · protein

Gpr domain of drosophila P5CS filament with glutamate and atpgammas

7WXI · Delta-1-pyrroline-5-carboxylate synthase: “Gpr domain of drosophila P5CS filament with glutamate and atpgammas”. Electron microscopy, 1 ligand (RGP), 11 pockets (best druggability 0.80). MolNFT v1 #190370 on GenesisL1: 3D structure…

PDB: 7WXI
Type: protein
Length: 860 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Delta-1-pyrroline-5-carboxylate synthase
EC: 2.7.2.11, 1.2.1.41
UniProt: Q9VNW6
Ligands: RGP
Pockets: 11 · best druggability 0.80

Structure

electron microscopy · 1 distinct chain · 42% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Delta-1-pyrroline-5-carboxylate synthase (EC 2.7.2.11, 1.2.1.41)	protein	430	42% helix, 12% strand	Q9VNW6

Ligands and binding sites

RGP · Gamma-glutamyl phosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1015	0.80	0.81	76	empty
2	749	0.77	0.82	41	empty
3	732	0.72	0.79	57	RGP
4	678	0.71	0.78	57	RGP
5	263	0.58	0.79	50	empty

Interfaces

1 interface between chains.

A–B · 2946 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

7WXI · GPR domain of Drosophila P5CS filament with glutamate and ATPgammaS · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9VNW6
Elsewhere: RCSB PDB 7WXI · PDBe 7WXI · UniProt Q9VNW6

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