MolNFT v1 · #190369 · protein

Gpr domain open form of drosophila P5CS filament with glutamate, ATP, and NADPH

7WXH · Delta-1-pyrroline-5-carboxylate synthase: “Gpr domain open form of drosophila P5CS filament with glutamate, ATP, and NADPH”. Electron microscopy, 13 pockets (best druggability 0.83). MolNFT v1 #190369 on GenesisL1: 3D structure…

PDB: 7WXH
Type: protein
Length: 860 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Delta-1-pyrroline-5-carboxylate synthase
EC: 2.7.2.11, 1.2.1.41
UniProt: Q9VNW6
Pockets: 13 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 40% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Delta-1-pyrroline-5-carboxylate synthase (EC 2.7.2.11, 1.2.1.41)	protein	430	40% helix, 16% strand	Q9VNW6

Pockets

13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1155	0.83	0.84	116	empty
2	674	0.78	0.83	57	empty
3	114	0.76	0.95	37	empty
4	124	0.74	0.93	38	empty
5	68	0.70	0.96	27	empty

Interfaces

1 interface between chains.

A–B · 2806 Å² buried · 36 hydrogen bonds · protein-protein

Compared structures

7WXH · GPR domain open form of Drosophila P5CS filament with glutamate, ATP, and NADPH · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9VNW6
Elsewhere: RCSB PDB 7WXH · PDBe 7WXH · UniProt Q9VNW6

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